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Unfortunately, due to the adverse reactions to the Johnson and Johnson Covid-19 vaccine, we are no longer able to accept appointments for this vaccine. Please check back for further updates as they become available.

We are working to obtain access to the Johnson & Johnson vaccine as quickly as possible. Please check our Facebook page for current updates.


3 months ago
Great drug store, they always have my meds. Filled on time, everyone that works there is always very nice and professional, I should have switched to this store years ago, I will never go back to the big chain stores again, thanks and keep up the great work you are doing there and I will refer people I know to you.
- Daniel m
2 years ago
The best in the upstate. Always kind and helpful. Brad and his team always go over and beyond to assist me. And they make positive impacts in our community. At Walgreens and CVS, you’re just a number. At Buford Street Pharmacy, you’re family. Like I said, they are the best.
- Curt D
2 years ago
We are a hometown pharmacy with a personal atmosphere. We would love the opportunity to earn your business. If you have any questions or would like to transfer your medications to us please feel free to call and speak with our staff.
- Amy H

About us

The mission of Buford Street Drug Store is to furnish the citizens of Cherokee County and surrounding areas with high quality and cost effective pharmaceutical services. We pride ourselves on delivering superior customer service in a prompt and sympathetic manner. 

Contact Us


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  • (864) 488-3036


Get directions
113 West Buford Street
Gaffney, South Carolina 29340
United States

Business Hours

Mon:9:00 AM – 6:00 PM
Tue:9:00 AM – 6:00 PM
Wed:9:00 AM – 6:00 PM
Thu:9:00 AM – 6:00 PM
Fri:9:00 AM – 6:00 PM
Sat:9:00 AM – 1:00 PM
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