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Unfortunately, due to the adverse reactions to the Johnson and Johnson Covid-19 vaccine, we are no longer able to accept appointments for this vaccine. Please check back for further updates as they become available.

We are working to obtain access to the Johnson & Johnson vaccine as quickly as possible. Please check our Facebook page for current updates.


8 months ago
The best in the upstate. Always kind and helpful. Brad and his team always go over and beyond to assist me. And they make positive impacts in our community. At Walgreens and CVS, you’re just a number. At Buford Street Pharmacy, you’re family. Like I said, they are the best.
- Curt D
8 months ago
We are a hometown pharmacy with a personal atmosphere. We would love the opportunity to earn your business. If you have any questions or would like to transfer your medications to us please feel free to call and speak with our staff.
- Amy H
5 years ago
I absolutely love this pharmacy! After moving from a place that my only options were the big chain stores like Walgreen, CVS etc... This store is just a dream come true! No more long drive through lines. My medications are always ready when they say the will be, and they always do their best to make sure I leave with a smile on my face. Such a friendly and happy crew. Not to mention, I love going into the store to browse through the fresh foods and canned goods! <3 If you happen to be self-pay, they can be a little pricey, but just a little more then the big chain pharmacies. I would much rather go in this store then spend the extra money in gas sitting for an hour in a line at the other stores, only to find out that they never finished filling your prescription, "so please drive around!"
- Amanda J

About us

The mission of Buford Street Drug Store is to furnish the citizens of Cherokee County and surrounding areas with high quality and cost effective pharmaceutical services. We pride ourselves on delivering superior customer service in a prompt and sympathetic manner. 

Contact Us


Call now
  • (864) 488-3036


Get directions
113 West Buford Street
Gaffney, South Carolina 29340
United States

Business Hours

Mon:9:00 AM – 6:00 PM
Tue:9:00 AM – 6:00 PM
Wed:9:00 AM – 6:00 PM
Thu:9:00 AM – 6:00 PM
Fri:9:00 AM – 6:00 PM
Sat:9:00 AM – 1:00 PM
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